CAS 39537-23-0 L-Alanyl-L-Glutamine For Clinical Nutrition And Sports Supplements Alanyl Glutamine

CAS 39537-23-0 L-Alanyl-L-Glutamine For Clinical Nutrition And Sports Supplements Alanyl Glutamine

Description

L-Alanyl-L-Glutamine is a highly stable, soluble dipeptide composed of the amino acids L-alanine and L-glutamine linked by a peptide bond. In the body, it is rapidly hydrolyzed to release its constituent amino acids. It serves as a superior source of glutamine, as free L-glutamine itself has poor stability and solubility in aqueous solutions. This dipeptide is widely used in clinical nutrition, sports supplements, and cell culture media due to its enhanced stability, bioavailability, and functional properties.

Specification Table

Key Features & Benefits

• Superior Stability: Remains stable under heat sterilization (autoclaving) and long-term storage in solution, unlike free glutamine which degrades to ammonia and pyroglutamic acid.
• High Solubility & Bioavailability: Offers extremely high solubility, allowing for concentrated formulations. It is efficiently absorbed in the gut and rapidly cleaved in the bloodstream to provide bioavailable L-glutamine and L-alanine.
• Cell Culture Advantages: In cell culture media, it prevents the buildup of toxic ammonia, promoting better cell growth, viability, and protein production (e.g., for monoclonal antibodies).
• Neutral Taste & Odor: Unlike some amino acids, it has a neutral taste profile, making it suitable for oral nutritional products without affecting flavor.
• Clinically Proven: Extensively researched for its role in supporting gut integrity, immune function, and nitrogen balance under metabolic stress.

Primary Applications

1. Clinical & Medical Nutrition:

   • Parenteral Nutrition (IV): A key component in intravenous solutions for critically ill, surgical, trauma, and burn patients to maintain glutamine levels, support immune cells, and preserve intestinal mucosa.
   • Enteral Nutrition (Tube-feeding): Included in formulas for patients with gastrointestinal disorders, cachexia, or severe catabolic conditions.

2. Sports Nutrition & Dietary Supplements:

   • Used in recovery drinks, protein powders, and endurance supplements to help reduce muscle soreness, support hydration and electrolyte transport, and bolster immune function after intense exercise.

3. Pharmaceuticals:

   • As an active pharmaceutical ingredient (API) or excipient in formulations targeting gut health and metabolic support.

4. Cell Culture Media:

   • An essential stable component of modern serum-free and chemically defined media for the biopharmaceutical industry (e.g., mammalian cell culture for vaccine and therapeutic protein production).

5. Animal Nutrition:

   • Used in premium feed for livestock, pets, and aquaculture to support growth, gut health, and stress recovery.